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Abcb1 and abcg2 mediate transport of abacavir and hinder its passage across the placenta

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: STAUD, Frantisek (Charles University, Faculty of Pharmacy, Pharmacology and toxicology, Hradec kralove, Czech Republic)
  • Co-author(s): Neumanova, Zuzana (Charles University, Faculty of Pharmacy, Hradec kralove, Czech Republic)
    Cerveny, Lukas (Charles University, Faculty of Pharmacy, Hradec kralove, Czech Republic)
  • Abstract:

    I. Background: Abacavir is a nucleoside reverse transcriptase inhibitor that is used in pregnant women to prevent mother-to-child-transmission of HIV infection. Together with other antiretroviral agents, it is administered throughout the whole period of pregnancy; however its transport across the placenta has not been fully elucidated to date.II...

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Last update 4 October 2019

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