The effects of gastric ph on the pharmacokinetics of atazanavir in healthy volunteers
- At: 2014 FIP Congress in PSWC, Melbourne (Australia)
- Type: Poster
- By: WU, Hsin-Fang (UCSF, San francisco, United States of America)
- Co-author(s): Faber, Kathleen (University of California-San Francisco, San francisco, United States of America)
Benet, Leslie Z. (University of California-San Francisco, San francisco, United States of America)
I.Significant pharmacokinetic interactions exist between gastric acid reducing agents and certain protease inhibitors, including atazanavir (ATV), which rely on acidic gastric pH for optimal absorption. In the presence of omeprazole, ATV exposure was reduced by 76% in healthy volunteers, raising the concern that concomitant administration of ATV.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.