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Dysfunction of a urate exporter abcg2 increases serum uric acid by decreased intestinal urate excretion

  • At: PSWC, Melbourne (Australia) (2014)
  • Type: Poster
  • By: TAKADA, Tappei (The University of Tokyo Hospital, Department of Pharmacy, Tokyo, Japan)
  • Co-author(s): Ichida, Kimiyoshi (Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan)
    Matsuo, Hirotaka (National Defense Medical College, Saitama, Japan)
    Nakayama, Akiyoshi (National Defense Medical College, Saitama, Japan)
    Suzuki, Hiroshi (The University of Tokyo Hospital, Tokyo, Japan)
  • Abstract:

    ATP-binding cassette transporter G2 (ABCG2), also known as breast cancer resistance protein (BCRP), is identified as a high-capacity urate exporter and its dysfunction has an association with serum uric acid (SUA) levels and gout/hyperuricemia risk. However, pathophysiologically important pathway(s) responsible for the ABCG2-mediated..

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Last update 4 October 2019

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