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Effect of cyclosporine a on hepato-biliary disposition of etoposide in an isolated perfused rat liver model

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: KHEZRIAN, Mina (Tehran University of Medical Sciences,Faculty of Pharmacy, Pharmaceutics, Tehran, Iran)
  • Co-author(s): Sheikholeslami (Lorestan University of Medical Sciences, Korramabad, Iran)
    Dadashzadeh (ShaheedBeheshti University of Medical Sciences, Tehran, Iran)
    Lavasani (Tehran University of Medical Sciences,Faculty of Pharmacy, Tehran, Iran)
    Rouini (Tehran University of Medical Sciences,Faculty of Pharmacy, Tehran, Iran)
  • Abstract:

    Background:Etoposide an anticancer agent is used in malignancies such as lung cancer and testis cancer .This chemotherapy agent is a substrate of drug transporter proteins in hepatocytes such as Multidrug-resistance associated proteins and P-glycoprotein. Cyclosporine A is a pharmacologic inhibitor of drug transporters .
    Aim:In this research an..

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Last update 4 October 2019

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