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Evaluation of the deacylation-reacylation metabolic cycle responsible for lymphatic transport of a triglyceride-mimetic prodrug

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: HAN, Sifei (Monash University, Drug Delivery, Disposition and Dynamics, Melbourne, Australia)
  • Co-author(s): Hu, Luojuan (Monash University, Melbourne, Australia)
    Quach, Tim (Monash University, Melbourne, Australia)
    Simpson, Jamie (Monash University, Melbourne, Australia)
    Trevaskis, Natalie (Monash University, Melbourne, Australia)
    Porter, Christopher (Monash University, Melbourne, Australia)
  • Abstract:

    Background
    In a previous study we described a triglyceride (TG) mimetic strategy to enhance drug delivery to the intestinal lymphatics following oral administration. This provides opportunities to improve the treatment of lymph-resident disease via enhanced (up to 100 fold) delivery to target sites and reduced (2.3 fold) off-target exposure to the ..

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Last update 4 October 2019

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