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Effect of drug transporters on hepatic distribution and pharmacokinetics of mefenamic acid and its acyl-conjugated metabolites

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: OKOCHI, Hideaki (UCSF, Bioengineering & Therapeutic Sciences, San francisco, United States of America)
  • Co-author(s): Horng, Howard (UCSF, San francisco, United States of America)
    Benet, Leslie Z. (UCSF, San francisco, United States of America)
  • Abstract:

    Background: Carboxylic acid non-steroidal anti-inflammatory drugs (NSAIDs) can be metabolized to reactive intermediates, such as -acyl-CoA, -acyl-S-glutathione (-SG) and -acyl-1-O-glucuronide (-1-O-G),which are capable of binding to proteins in the blood and tissues. We speculate that covalent binding of these reactive metabolites to proteins may..

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Last update 4 October 2019

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