Effect of drug transporters on hepatic distribution and pharmacokinetics of mefenamic acid and its acyl-conjugated metabolites
- At: 2014 FIP Congress in PSWC, Melbourne (Australia)
- Type: Poster
- By: OKOCHI, Hideaki (UCSF, Bioengineering & Therapeutic Sciences, San francisco, United States of America)
- Co-author(s): Horng, Howard (UCSF, San francisco, United States of America)
Benet, Leslie Z. (UCSF, San francisco, United States of America)
Background: Carboxylic acid non-steroidal anti-inflammatory drugs (NSAIDs) can be metabolized to reactive intermediates, such as -acyl-CoA, -acyl-S-glutathione (-SG) and -acyl-1-O-glucuronide (-1-O-G),which are capable of binding to proteins in the blood and tissues. We speculate that covalent binding of these reactive metabolites to proteins may.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.