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Enhancement of percutaneous penetration of actarit from hydrophilic gel using penetration enhancers

  • At: PSWC, Melbourne (Australia) (2014)
  • Type: Poster
  • By: PUND, Swati (STES's Sinhgad Institute of Pharmacy, Pharmaceutics, Pune, India)
  • Co-author(s): Mehta, Ratnesh (STES's Sinhgad Institute of Pharmacy, Pune, India)
    Thakur, Rohit (STES's Sinhgad Institute of Pharmacy, Pune, India)
    Dhat, Shalaka (STES's Sinhgad Institute of Pharmacy, Pune, India)
  • Abstract:

    Actarit (4-acetylaminophenylacetic acid), reduces TNFα and IL-1β secretion by primary synovial cells of patients with rheumatoid arthritis (RA) and therefore, effectively suppresses progression of disease. Gastrointestinal side effects after oral administration and poor and slow aqueous solubility are the major therapeutic limitations..

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Last update 4 October 2019

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