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Optimization of spray dried microspheres for pulmonary inhalation development: exploring a new drug delivery route for melatonin

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: ZHAO, Min (UCL School of Pharmacy, Department of Pharmaceutics, London, United Kingdom)
  • Co-author(s): Samaro, Aseel (UCL School of Pharmacy, London, United Kingdom)
    Orlu Gul, Mine (UCL School of Pharmacy, London, United Kingdom)
    Casati, Federica (UCL School of Pharmacy, London, United Kingdom)
  • Abstract:

    Background: Melatonin, a drug for the treatment of insomnia, has a very low oral bioavailability (15%) mainly due to the extensive first pass metabolism in the liver. This leads to great interest in establishing whether pulmonary dry powder inhalation (DPI) is a promising route to deliver melatonin as a means of improving the bioavailability.
    Aim: ..

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Last update 4 October 2019

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