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In vitro transport studies across excised nasal mucosa for three drug candidates to nose-to-brain delivery

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: COLOMBO, Gaia (University of Ferrara, Life Sciences and Biotechnology, Ferrara, Italy)
  • Co-author(s): Bortolotti, Fabrizio (University of Ferrara, Ferrara, Italy)
    Sonvico, Fabio (University of Technology Sydney, Sydney, Australia)
    Balducci, Anna Giulia (Interdepartmental Center, Biopharmanet-TEC, University of Parma, Parma, Italy)
    Rossi, Alessandra (University of Parma, Parma, Italy)
    Colombo, Paolo (University of Parma, Parma, Italy)
    Buttini, Francesca (University of Parma, Parma, Italy)
  • Abstract:

    I. Nasal administration allows for direct transport of active substances from the olfactory epithelium to the brain. In nose-to-brain drug delivery in vitro methods can be set up to study permeation characteristics and guide formulation development.
    II. To study the permeation of antiviral ribavirin, inverse agonist for the cannabinoid receptor..

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Last update 4 October 2019

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