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Lipidation of a peptide; effects on activity and epidermal permeability in vitro

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: CACCETTA, Rima (Curtin University, School of Pharmacy (CHIRI), Perth wa, Australia)
  • Co-author(s): Rocco (Curtin University, Perth wa, Australia)
    Ross (Curtin University, Perth wa, Australia)
    Murray (Curtin University, Perth wa, Australia)
  • Abstract:

    Introduction:
    The tetrapeptide Ala-Ala-Pro-Val, a human neutrophil elastase inhibitor, represents a potential therapeutic for psoriasis. Direct topical delivery of this peptide is preferred; however, this is impeded by the stratum corneum. Lipidation provides a means to increase peptide delivery across the epidermis. Previous attempts at..

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Last update 4 October 2019

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