Improved dissolution and oral exposure of telmisartan, a poorly soluble drug through the formation of drug-clay complex
- At: 2014 FIP Congress in PSWC, Melbourne (Australia)
- Type: Poster
- By: YANG, Liang (Dongguk University, College of Pharmacy, Goyang, South-Korea)
- Co-author(s): Han, Hyo-Kyung (Dongguk University, Goyang, South-Korea)
Ⅰ. Background: Telmisartan, an antihypertensive drug, belongs to BCS Class II (low solubility/high permeability) and exhibits pH-dependent solubility.
Ⅱ. Aims: Since 3-aminopropyl functionalized magnesium phyllosilicate (aminoclay) can intercalate or adsorb the negatively charged drugs via the electrostatic interaction, we synthesized the.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.