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Improved dissolution and oral exposure of telmisartan, a poorly soluble drug through the formation of drug-clay complex

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: YANG, Liang (Dongguk University, College of Pharmacy, Goyang, South-Korea)
  • Co-author(s): Han, Hyo-Kyung (Dongguk University, Goyang, South-Korea)
  • Abstract:

    . Background: Telmisartan, an antihypertensive drug, belongs to BCS Class II (low solubility/high permeability) and exhibits pH-dependent solubility.
    . Aims: Since 3-aminopropyl functionalized magnesium phyllosilicate (aminoclay) can intercalate or adsorb the negatively charged drugs via the electrostatic interaction, we synthesized the..

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Last update 4 October 2019

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