Engineering of a novel, sterically hindered disulphide bridged amino acid: enhanced biostability leading to new generation bioreducible peptides and drug/gene carrier systems
- At: 2014 FIP Congress in PSWC, Melbourne (Australia)
- Type: Poster
- By: TUPALLY, Karnaker (University of Queensland, School of Pharmacy, Brisbane, Australia)
- Co-author(s): Parekh, Harendra (University of Queensland, Brisbane, Australia)
Defang, Ouyang (Aston University, Birmingham, United Kingdom)
Thiol-disulfide exchange (redox) chemistry is essential to the maintenance of homeostasis, both in the intra- and extracellular environments of living organisms. The stark contrast in glutathione (GSH) levels between these environments can be exploited when designing therapeutics and drug/gene carrier systems. Here, strategic incorporation of.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.