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Engineering of a novel, sterically hindered disulphide bridged amino acid: enhanced biostability leading to new generation bioreducible peptides and drug/gene carrier systems

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: TUPALLY, Karnaker (University of Queensland, School of Pharmacy, Brisbane, Australia)
  • Co-author(s): Parekh, Harendra (University of Queensland, Brisbane, Australia)
    Defang, Ouyang (Aston University, Birmingham, United Kingdom)
  • Abstract:

    Thiol-disulfide exchange (redox) chemistry is essential to the maintenance of homeostasis, both in the intra- and extracellular environments of living organisms. The stark contrast in glutathione (GSH) levels between these environments can be exploited when designing therapeutics and drug/gene carrier systems. Here, strategic incorporation of..

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Last update 4 October 2019

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