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Surface treated methotrexate-loaded nanogels as 'trojan horses' for brain drug delivery

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: AZADI, Amir (Tehran University of Medical Sciences, Biopharmaceutics and Pharmacokinetic Division, Department of Pharmaceutics, Tehran, Iran)
  • Co-author(s): Hamidi, Mehrdad (Zanjan University of Medical Sciences, Zanjan, Iran)
    Rouini, Mohammad Reza (Tehran University of Medical Sciences, Tehran, Iran)
  • Abstract:

    Background: Delivery of the hydrophilic drugs such as methotrexate (MTX) to the brain is still a great challenge for the treatment of many CNS-related diseases.
    Aim: The aim of this study was the preparation of a nanocarrier for brain enhancement of this BBB-restricted hydrophilic drug.
    Methods: nanogels loaded with the MTX were prepared using an..

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Last update 4 October 2019

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