Surface treated methotrexate-loaded nanogels as 'trojan horses' for brain drug delivery
- At: 2014 FIP Congress in PSWC, Melbourne (Australia)
- Type: Poster
- By: AZADI, Amir (Tehran University of Medical Sciences, Biopharmaceutics and Pharmacokinetic Division, Department of Pharmaceutics, Tehran, Iran)
- Co-author(s): Hamidi, Mehrdad (Zanjan University of Medical Sciences, Zanjan, Iran)
Rouini, Mohammad Reza (Tehran University of Medical Sciences, Tehran, Iran)
Background: Delivery of the hydrophilic drugs such as methotrexate (MTX) to the brain is still a great challenge for the treatment of many CNS-related diseases.
Aim: The aim of this study was the preparation of a nanocarrier for brain enhancement of this BBB-restricted hydrophilic drug.
Methods: nanogels loaded with the MTX were prepared using an.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.