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Lipoprotein association plays a critical role in promoting lymphatic transport of a biomimetic prodrug of mycophenolic acid

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: HAN, Sifei (Monash University, Drug Delivery, Disposition and Dynamics, Melbourne, Australia)
  • Co-author(s): Hu, Luojuan (Monash University, Melbourne, Australia)
    Quach, Tim (Monash University, Melbourne, Australia)
    Simpson, Jamie (Monash University, Melbourne, Australia)
    Trevaskis, Natalie (Monash University, Melbourne, Australia)
    Porter, Christopher (Monash University, Melbourne, Australia)
  • Abstract:

    Background
    Following ingestion, dietary triglycerides (TG), are transported via the intestinal lymphatic system - in the form of enterocyte-assembled lipoproteins (LP). Inspired by this unique metabolic pathway, a TG mimetic prodrug (MPA-TG, Fig. 1) was conceived and demonstrated in our previous studies to markedly promote the delivery of..

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Last update 4 October 2019

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