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Selection of polymeric precipitation inhibitors for use with poorly water soluble drugs

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: WARREN, Dallas (Monash Institute of Pharmaceutical Science, Drug Delivery, Disposition and Dynamics, Parkville, Australia)
  • Co-author(s): Bergstr, Christel A.S. (Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Uppsala, Sweden)
    Benameur, Hassan (Capsugel R&D, Strasbourg, France)
    Williams, Hywel (Capsugel R&D, Strasbourg, France)
    Porter, Christopher (Monash Institute of Pharmaceutical Science, Parkville, Australia)
    Pouton, Colin (Monash Institute of Pharmaceutical Science, Parkville, Australia)
  • Abstract:

    I
    The presence of polymers within solid dose dispersions and lipid based formulations, can promote the maintenance of drug supersaturation after dissolution or dispersion/digestion of the vehicle in the gastrointestinal tract.
    II
    To provide a deeper understanding of the molecular determinants of polymer precipitation inhibition the precipitation..

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Last update 4 October 2019

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