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Improved oral bioavailability and reduced nephrotoxicity of self-emulsifying formulation of cyclosporin a in combination with antioxidant following oral administration

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: JAIN, Sanyog (National Institute of Pharmaceutical Education and Research (NIPER), Department of Pharmaceutics, Sas nagar, India)
  • Co-author(s): Kambam, Sindu (National Institute of Pharmaceutical Education and Research (NIPER), Sas nagar, India)
    Jain, Amit Kumar (National Institute of Pharmaceutical Education and Research (NIPER), Sas nagar, India)
  • Abstract:

    Background: Cyclosporin A(CyA) is commercially available as self-emulsifying drug delivery system (SEDDS) (Neoral®, Bioral®) yet drug-induced nephrotoxicity is the major challenge.
    Aim: SEDDS of CyA in combination with an antioxidant (Vitamin E TPGS) were developed with the aim to improve bioavailability and reduce nephrotoxicity.
    Methods:..

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Last update 4 October 2019

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