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L-asparaginase-fatty acid bioconjugates in nanostructured mixed micelles: synthesis, biochemical/biophysical characterization, immunogenicity and pharmacokinetic analysis of peptidic anticancer agent

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: DANESHAMOUZ, Saeid (School of Pharmacy, Shiraz University of Medical Sciences, Pharmaceutics, Pharmaceutical Nanotechnology, Shiraz, Iran)
  • Co-author(s): Ashrafi, Hajar (Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shiraz university of medical sciences, Iran)
    Amini, Mohsen (Department of Medicinal Chemistry and Drug Design and Development ResearchCentre, Tehran university of medical sciences, Iran)
    Mohammadi-Samani, Soliman (Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shiraz university of medical sciences, Iran)
    Ghasemi, Younes (Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shiraz university of medical sciences, Iran)
    Kamali-Sarvestani, Eskandar (Autoimmune Diseases Research Center, Shiraz Medical School, Shiraz university of medical sciences, Iran)
    Azadi, Amir (Department of Pharmaceutics, Faculty of Pharmacy, Tehran university of medical sciences, Iran)
  • Abstract:

    Background: L-Asparaginase is a peptidic anticancer for acute lymphoblastic leukemia with short in vivo half-life and low stability thus necessitating multiple injections.
    Aims: Presenting a novel delivery system based on conjugation of L-Asparaginase with short, medium and long chain fatty acids (C12, C16 and C22) and subsequently to form self..

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Last update 4 October 2019

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