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A novel microtubule polymerization inhibitor with potent antiproliferative and antitumor activity, but not a substrate for pgp and mrp

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: CHEN, Lijuan (West China Medical School, Sichuan University, State Key Laboratory of Biotherapy, Chengdu, China)
  • Co-author(s): Han, Xiaolei (West China Medical School, Sichuan University, Chengdu, China)
    Wu, Wenshuang (West China Medical School, Sichuan University, Chengdu, China)
    Tang, Minghai (West China Medical School, Sichuan University, Chengdu, China)
    Wang, Guangcheng (West China Medical School, Sichuan University, Chengdu, China)
  • Abstract:

    Background:Microtubules play important roles in key cell events especially in mitosis and make it become an attractive target for anti-cancer drugs design,In this study, we further depicted the in vitro and in vivo effects of one lead compound from the series 3-(4-(Diethyl amino) phenyl)-1-(5-methoxy-2, 2-dimethyl-2H-chromen-8-yl)..

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Last update 4 October 2019

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