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Lipophilic prodrugs for oral chemotherapy: synthesis, stability and cytotoxicity

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: BALA, Vaskor (Ian Wark Research Institute, University of South Australia, Mawson Lakes, Adelaide, Australia)
  • Co-author(s): Rao, Sasha (Ian Wark Research Institute, University of South Australia, Mawson lakes, Australia)
    Wang, Shudong (School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia)
    Boyd, Ben J. (Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia)
    Prestidge, Clive (Ian Wark Research Institute, University of South Australia, Mawson lakes, Australia)
  • Abstract:

    Background: SN38 is a potent semisynthetic anticancer agent of the camptothecin (CPT) family. Akin to other CPTs, SN38's direct formulation is challenged by poor solubility in pharmaceutically approved solvents. We hypothesize that a lipophilic prodrug approach coupled with lipid-based formulation will facilitate efficacious oral delivery of SN38.
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Last update 4 October 2019

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