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Synthesis and characterisation of sterically hindered pyridine based multinuclear platinum anticancer complexes and their cytotoxicity

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: APPS, Michael G. (The University of Sydney, Faculty of Pharmacy, Camperdown, Australia)
  • Co-author(s): Ammit, Alaina J. (The University of Sydney, Camperdown, Australia)
    Wheate, Nial J. (The University of Sydney, Camperdown, Australia)
  • Abstract:

    I. Background
    Multinuclear platinum drugs, such as BBR3464, are of current interest due to their higher activity compared to cisplatin and their retained activity in cisplatin resistant cells. They are however extremely toxic and susceptible to degradation. A current drug undergoing clinical trials, picoplatin, has a sterically hindered platinum..

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Last update 4 October 2019

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