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A novel non-immune phage human antibody library comprising four stable vh-vl pairs

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: MUKAI, Yohei (National Institute of Biomedical Innovation, Center for Drug Innovation and Screening, Osaka, Japan)
  • Co-author(s): Ogura (Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan)
    Misato (Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan)
    Nagano (Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan)
    Higashisaka (Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan)
    Yoshioka (Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan)
    Nagano (National Institute of Biomedical Innovation, Osaka, Japan)
    Kamada (National Institute of Biomedical Innovation, Osaka, Japan)
    Tsunoda (National Institute of Biomedical Innovation, Osaka, Japan)
    Tsutsumi (Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan)
  • Abstract:

    A non-immune phage human antibody library is a powerful tool for isolating human monoclonal antibodies (mAbs). In this system, billions of human mAb repertoires are displayed on M13 phage populations, allowing for the isolation of antigen-specific mAbs via in vitro selection within 2 weeks. VH-VL pairs were recently revealed to be important for..

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Last update 4 October 2019

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