Unravelling the gc functionality in the neurotrophic tyrosine kinase, ntrk1

• In: Posters C - Drug Design and Discovery
• At: PSWC, Melbourne (Australia) (2014)
• Type: Poster
• Poster code: PC-019
• By: VYAS, Jignesh (Monash Institute for Pharmaceutical Sciences, Drug Discovery Biology, Melbourne, Australia)
• Co-author(s): Freihat, Lubna (Monash Institute for Pharmaceutical Sciences, Melbourne, Australia)
  Wheeler, Janet (Monash Institute for Pharmaceutical Sciences, Melbourne, Australia)
  Muleya, Victor (Monash Institute for Pharmaceutical Sciences, Melbourne, Australia)
  Irving, Helen (Monash Institute for Pharmaceutical Sciences, Melbourne, Australia)
  
• Abstract:

  NTRK1 is a high affinity tyrosine kinase receptor for Nerve Growth Factor (NGF) and it plays an important role in regulating cell proliferation, differentiation and programmed cell death. Mutation in NTRK1 gene leads to several pathological conditions which include congenital insensitivity to pain with anhidrosis (CIPA), and it also has oncogenic..

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