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A novel synthetic prodrug of flurbiprofen with good oral drug-like behaviors and improved safety profile

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: YANG, Ling (Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China, Laboratory of Pharmaceutical Resource Discovery, Dalian, China)
  • Co-author(s): Ning, Jing (Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China)
    Ge, Guang-Bo (Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China)
    Li, Yan (Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China)
    Li, Shi-Yang (Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China)
  • Abstract:

    Background: Flurbiprofen (FPF), a clinical used non-steroidal anti-inflammatory drug (NSAID), causes serious gastrointestinal (GI) adverse events including inflammation, bleeding, ulceration, and perforation.
    Aims: To improve its oral drug-like behaviors and safety profile, a series of prodrugs for flurbiprofen were designed based on the tissue..

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Last update 4 October 2019

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