Retinoic acid activity on mamalian embryo in organ culture and evaluation of hazard and risk in correlation studies between molecular descriptors and admet parameters in a series of x-category drugs

• In: Posters C - Drug Design and Discovery
• At: PSWC, Melbourne (Australia) (2014)
• Type: Poster
• Poster code: PC-006
• By: JADRIJEVIC-MLADAR TAKAC, Milena (Faculty of Pharmacy and Biochemistry, University of Zagreb, Department of Medicinal chemistry, Zagreb, Croatia)
• Co-author(s): Crnek-Kunstelj, Vesna (Medical School Zagreb, Zagreb, Croatia)
  Barbaric, Monika (Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia)
  Takac, Vedran (Health Institution Stefanic Pharmacies, Zagreb, Croatia)
  
• Abstract:

  The results of our previous work on mammalian embryo-derived teratomas in organ culture treated with either retinoic acid (RA, c = 10^-5 mol/L) or neural growth factor (NGF, 100 ng/mL) showed no influence on neural tissue differentiation. On the contrary the combination of RA and NGF influenced neural tissue differentiation (100%) and inhibition of ..

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