Retinoic acid activity on mamalian embryo in organ culture and evaluation of hazard and risk in correlation studies between molecular descriptors and admet parameters in a series of x-category drugs
- At: 2014 FIP Congress in PSWC, Melbourne (Australia)
- Type: Poster
- By: JADRIJEVIC-MLADAR TAKAC, Milena (Faculty of Pharmacy and Biochemistry, University of Zagreb, Department of Medicinal chemistry, Zagreb, Croatia)
- Co-author(s): Crnek-Kunstelj, Vesna (Medical School Zagreb, Zagreb, Croatia)
Barbaric, Monika (Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia)
Takac, Vedran (Health Institution Stefanic Pharmacies, Zagreb, Croatia)
The results of our previous work on mammalian embryo-derived teratomas in organ culture treated with either retinoic acid (RA, c = 10-5 mol/L) or neural growth factor (NGF, 100 ng/mL) showed no influence on neural tissue differentiation. On the contrary the combination of RA and NGF influenced neural tissue differentiation (100%) and inhibition of .. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.