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Relationships between molecular descriptors, drug-likeness scores, admet parameters and biological activity of tyrosine kinase inhibitors in a series of quinoline, quinazoline, pyrido- and pyrimido-pyrimidine derivatives

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: JADRIJEVIC-MLADAR TAKAC, Milena (Faculty of Pharmacy and Biochemistry, University of Zagreb, Department of Medicinal chemistry, Zagreb, Croatia)
  • Co-author(s): Takac, Vedran (Health Institution Stefanic Pharmacies, Zagreb, Croatia)
    Barbaric, Monika (Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia)
    Crnek-Kunstelj, Vesna (Medical School Zagreb, Zagreb, Croatia)
  • Abstract:

    The design of specific inhibitors of protein tyrosine kinases (PTKIs) is important both for fundamental research and for therapeutic strategies development in treatment of diseases such as cancer.
    The aim of this work was to explore the relationships between molecular descriptors (MDs), drug-likeness scores (DLs) and ADMET parameters of PTKIs,..

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Last update 4 October 2019

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