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Structural change of biopharmaceuticals using ion mobility mass spectrometry analysis

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: KAMADA, Haruhiko (National Institute of Biomedical Innovation, Laboratory of Biopharmaceutical Research, Ibaraki,, Japan)
  • Co-author(s): Inoue (National Institute of Biomedical Innovation, Ibaraki,, Japan)
    Nagano (National Institute of Biomedical Innovation, Ibaraki,, Japan)
    Mukai (National Institute of Biomedical Innovation, Ibaraki,, Japan)
    Higashisaka (Osaka University, Suita, Japan)
    Yoshioka (Osaka University, Suita, Japan)
    Tsutsumi (Osaka University, Suita, Japan)
    Tsunoda (National Institute of Biomedical Innovation, Ibaraki,, Japan)
  • Abstract:

    Protein misfolding could in many cases underlie the immunogenicity of biopharmaceuticals. Conformational changes of biopharmaceuticals can also affect their potency because the correct structure is important for binding and signal transduction. Ion mobility mass spectrometry (IM-MS), which can separate different-sized molecules with an ion..

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Last update 4 October 2019

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