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Interaction with mixed micelles in the intestine attenuates the permeation enhancing potential of alkyl-maltosides

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Presentation
  • By: GRADAUER, Kerstin (Novo Nordisk A/S, ADME Department, M, Denmark)
  • Co-author(s): Nishiumi (Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan)
    Unrinin (Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan)
    Kataoka (Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan)
    Pedersen (Novo Nordisk A/S, M, Denmark)
    Buckley (Novo Nordisk A/S, M, Denmark)
    Yamashita (Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan)
  • Abstract:

    Background: Oral delivery of protein therapeutics is severely hindered by poor absorption across the intestinal barrier. Although many permeation enhancers have been shown to improve their absorption, no oral product incorporating a permeation enhancer has been marketed for clinical use to date. In order to develop an efficient oral delivery

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Last update 4 October 2019

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