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Transforming toxins into therapeutics: potassium channel blockers as treatments for autoimmune diseases

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Presentation
  • By: NORTON, Raymond Stanley (Monash Institute of Pharmaceutical Sciences, Medicinal Chemistry, Parkville, Australia)
  • Abstract:

    Background: Effector memory T cells, which are involved in autoimmune diseases such as multiple sclerosis (MS), type 1 diabetes mellitus and rheumatoid arthritis (RA), express Kv1.3 potassium channels, which play a major role in their activation. Blockers of lymphocyte Kv1.3 channels selectively inhibit the activation of these cells and therefore..

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Last update 4 October 2019

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