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Effects of the mobile phase composition on the determination of the kinetic rate constant of flurbiprofen-cyclodextrin supramolecular

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Presentation
  • By: ZHANG, Jiwen (Shanghai Institute Materia Medica, Chinese Academy of Sciences, Shanghai, China)
  • Co-author(s): Li, Haiyan (Shanghai Institute Materia Medica, Chinese Academy of Sciences, Shanghai, China)
    Ge, Jingwen (Shanghai Institute Materia Medica, Chinese Academy of Sciences, Shanghai, China)
    Wang, Caifen (School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China)
    Guo (Shanghai Institute Materia Medica, Chinese Academy of Sciences, Shanghai, China)
    He, Zhonggui (School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China)
    York, Peter (Institute of Pharmaceutical Innovation, University of Bradford, Bradford, United Kingdom)
    Sun, Lixn (School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China)
    Xu, Xu (Shanghai Institute of Technology, Shanghai, China)
  • Abstract:

    Background. The kinetics of dissociation is fundamental to the in vivo functions of supramolecules. However, it is extremely difficult to measure the kinetics of supramolecular systems with weak binding (Ka <105 M-1) and fast dissociation (relaxation time <1s), such as drug-cyclodextrins supramolecules. A modified peak profiling method based on..

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Last update 4 October 2019

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