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Suppression of lipopolysaccharide-induced macrophage activation by aliphatic amine-heparin conjugates

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Presentation
  • By: YANAMOTO, Shinya (Graduate School of Pharmaceutical Sciences Kyoto University, Kyoto, Japan)
  • Co-author(s): Hasan, Babazada (Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan)
    Yamashita, Fumiyoshi (Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan)
    Hashida, Mitsuru (Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan)
  • Abstract:

    There has been considerable interest in the potential anti-inflammatory properties of heparin which mainly comes from its capability to bind and inhibit proteins critically involved in the inflammatory process. We recently found that, more significantly than native heparin, sphingosine-heparin conjugates suppressed production of inflammation..

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Last update 4 October 2019

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