Synthesis and anticancer activity of 2-substituted aminomethyl-5-methylenecyclopentanones as apoptosis inducers through down-regulating c-flip
- At: 2014 FIP Congress in PSWC, Melbourne (Australia)
- Type: Presentation
- By: ZHAO, Linxiang (Shenyang Pharmaceutical University, Shenyang, China)
- Co-author(s): Liu, Dan (Shenyang Pharmaceutical University, Shenyang, China)
Jing, Yongkui (Mount Sinai School of Medicine, NewYork, United States of America)
Mitochindrial-mediated apoptosis pathway is a main mechanism of action of chemotherapy-induced cell death in cancer. Since resistance and relpase usually occur in cancers originally responded to chemotherapy, to activate the altherantive death-receptor-mediated pathway should significantly improve the therapeutic outcome of cancer treatment... The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.