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Synthesis and anticancer activity of 2-substituted aminomethyl-5-methylenecyclopentanones as apoptosis inducers through down-regulating c-flip

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Presentation
  • By: ZHAO, Linxiang (Shenyang Pharmaceutical University, Shenyang, China)
  • Co-author(s): Liu, Dan (Shenyang Pharmaceutical University, Shenyang, China)
    Jing, Yongkui (Mount Sinai School of Medicine, NewYork, United States of America)
  • Abstract:

    Mitochindrial-mediated apoptosis pathway is a main mechanism of action of chemotherapy-induced cell death in cancer. Since resistance and relpase usually occur in cancers originally responded to chemotherapy, to activate the altherantive death-receptor-mediated pathway should significantly improve the therapeutic outcome of cancer treatment...

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Last update 4 October 2019

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