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Computational prediction of apparent solubility of lipophilic drug molecules in fasted state simulated intestinal fluid

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Presentation
  • By: FAGERBERG, Jonas (Uppsala Universty, Pharmacy, Uppsala, Sweden)
  • Co-author(s): Karlsson, Eva (AstraZeneca R&D, M, Sweden)
    Ulander, Johan (AstraZeneca R&D, M, Sweden)
    S, Erik (AstraZeneca R&D, M, Sweden)
    Bergström, Christel A.S. (Uppsala Universty, Uppsala, Sweden)
  • Abstract:

    Background: Solubility in intestinal fluids is a key parameter affecting the bioavailability of drugs. Aim: To develop a computational model for prediction of apparent solubility of lipophilic drugs in fasted state simulated intestinal fluid (FaSSIF), a biorelevant medium mimicking the intestinal fluid. Methods: Apparent solubility (Sapp) values

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Last update 4 October 2019

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