Solubility and formulate-ability: key molecular determinants of developability of ligands to contemporary targets
- At: PSWC, Melbourne (Australia) (2014)
- Type: Presentation
- By: BERGSTROM, Christel A.S. (Uppsala University, Pharmacy, Uppsala, Sweden)
Large research efforts are currently directed towards solubility enhancing strategies due to the poor solubility profile of new chemical entities (NCEs). The molecular reasons for poor solubility are related to the strength of intermolecular bonds in the solid material of the drug and the strength of the bonds formed between the drug and the water .. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.