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pKa Determination of Polyprotic Acids and Bases by 1H-NMR

  • At: 2013 FIP Congress in Dublin (Ireland)
  • Type: Poster
  • By: BEZENçON, Jacqueline (University of Basel, Institute of Molecular Pharmacy, Basel, Switzerland)
  • Co-author(s): Wittwer, Matthias (University of Basel, Institute of Molecular Pharmacy, Basel, Switzerland)
    Cutting, Brian (University of Basel, Institute of Molecular Pharmacy, Basel, Switzerland)
    Kleeb, Simon (University of Basel, Institute of Molecular Pharmacy, Basel, Switzerland)
    Ernst, Beat (University of Basel, Institute of Molecular Pharmacy, Basel, Switzerland)
  • Abstract:

    In drug discovery and development, pKa values are of upmost importance for the prediction of pharmacokinetic and pharmacodynamic properties of a compound. The pKa value has a direct impact on aqueous solubility as well as permeability through biological membranes. Ionized molecules show an increased polarity compared to neutral molecules and..

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Last update 4 October 2019

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