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Development and validation for the simultaneous determination of ethanol content and organic volatile impurities in reservoir-type fentanyl transdermal delivery system by gas chromatography

  • At: 2006 FIP Congress in Salvadore (Brazil)
  • Type: Poster
  • By: LU, Kuan-Hung (National Bureau of Controlled Drugs, Taipei, China Taiwan)
  • Co-author(s): Chen, Ching-Yuan (National Bureau of Controlled Drugs, TAIPEI, China Taiwan)
    Hu, Jun-Ming (National Bureau of Controlled Drugs, TAIPEI, China Taiwan)
    Shih, Hui-Chuan (National Bureau of Controlled Drugs, TAIPEI, China Taiwan)
    Shih, Ru-Liang (National Bureau of Controlled Drugs, TAIPEI, China Taiwan)
    Chin, Fwu-Show (National Bureau of Controlled Drugs, TAIPEI, China Taiwan)
    Chien, Chun-Sheng (National Bureau of Controlled Drugs, TAIPEI, China Taiwan)
  • Abstract:

    An ethanol/water cosolvent system was applicably used as a vehicle in the reservoir-type fentanyl transdermal delivery system. Since ethanol acts as a skin permeation enhancer, the assay of ethanol content is an important criterion of quality control under good manufacturing practices (GMP). Furthermore, the determination of organic volatile

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Last update 4 October 2019

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