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Evaluation of predictive pharmacokinetic-pharmacodynamic software coupled with Bayesian method for carbapenem therapy in patients with pneumonia

  • At: 2013 FIP Congress in Dublin (Ireland)
  • Type: Poster
  • By: ISHIHARA, Noriyuki (Shimane University Hospital, Pharmacy, Izumo-shi, Japan)
  • Co-author(s): Nishimura, Nobuhiro (Shimane University Hospital, Izumo-shi, Japan)
    Karino, Fumi (Shimane University Faculty of Medicine, Izumo-shi, Japan)
    Miura, Kiyotaka (Shimane University Faculty of Medicine, Izumo-shi, Japan)
    Isobe, Takeshi (Shimane University Faculty of Medicine, Izumo-shi, Japan)
    Ikawa, Kazuro (Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima-shi, Japan)
    Morikawa, Norifumi (Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima-shi, Japan)
    Naora, Kohji (Shimane University Hospital, Izumo-shi, Japan)
  • Abstract:

    Background:

    The fraction of time during the dosing interval that the drug concentration exceeds its MIC (T > MIC) is the pharmacokinetic-pharmacodynamic (PK-PD) parameter that correlates with the bactericidal and clinical efficacy of carbapenem antibiotics. However, there have been few clinical researches on individualized therapy with the..

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Last update 4 October 2019

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