Evaluation of predictive pharmacokinetic-pharmacodynamic software coupled with Bayesian method for carbapenem therapy in patients with pneumonia

• In: Posters
• At: Dublin (Ireland) (2013)
• Type: Poster
• By: ISHIHARA, Noriyuki (Shimane University Hospital, Pharmacy, Izumo-shi, Japan)
• Co-author(s): Nishimura, Nobuhiro (Shimane University Hospital, Izumo-shi, Japan)
  Karino, Fumi (Shimane University Faculty of Medicine, Izumo-shi, Japan)
  Miura, Kiyotaka (Shimane University Faculty of Medicine, Izumo-shi, Japan)
  Isobe, Takeshi (Shimane University Faculty of Medicine, Izumo-shi, Japan)
  Ikawa, Kazuro (Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima-shi, Japan)
  Morikawa, Norifumi (Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima-shi, Japan)
  Naora, Kohji (Shimane University Hospital, Izumo-shi, Japan)
  
• Abstract:

  Background:
  
  The fraction of time during the dosing interval that the drug concentration exceeds its MIC (T > MIC) is the pharmacokinetic-pharmacodynamic (PK-PD) parameter that correlates with the bactericidal and clinical efficacy of carbapenem antibiotics. However, there have been few clinical researches on individualized therapy with the..

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