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Physical solid-state properties and stability of piroxicam containing solid dispersions obtained by means of cryogenic co-grinding

  • At: 2013 FIP Congress in Dublin (Ireland)
  • Type: Poster
  • By: HEINäMäKI, Jyrki (University of Tartu, Faculty of Medicine, Department of Pharmacy, Tartu, Estonia)
  • Co-author(s): Penkina, Anna (Department of Pharmacy, Faculty of Medicine, University of Tartu, Tartu, Estonia)
    Semjonov, Kristian (Department of Pharmacy, Faculty of Medicine, University of Tartu, Tartu, Estonia)
    Hakola, Maija (Department of Chemistry, Faculty of Science, University of Helsinki, Helsinki, Finland)
    Vuorinen, Sirpa (Department of Chemistry, Faculty of Science, University of Helsinki, Helsinki, Finland)
    Repo, Timo (Department of Chemistry, Faculty of Science, University of Helsinki, Helsinki, Finland)
    Kirsimäe, Kalle (Institute of Ecology and Earth Sciences, University of Tartu, Tartu, Estonia)
    Yliruusi, Jouko (Div. of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland)
    Veski, Peep (Department of Pharmacy, Faculty of Medicine, University of Tartu, Tartu, Estonia)
    Kogermann, Karin (Department of Pharmacy, Faculty of Medicine, University of Tartu, Tartu, Estonia)
  • Abstract:

    The metastable amorphous form of drug has better dissolution and bioavailability properties compared to the corresponding crystalline form. The aim of the present study was to investigate polyvinylpyrrolidone (PVP) and catalytic pretreated cellulose (CPSC) as carrier polymers in cryogenic co-grinding (amorphisation) of poorly water-soluble..

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Last update 4 October 2019

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