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Design, synthesis, and biological evaluation of memantine-polyamine conjugates as NMDA channel blockers

  • At: 2013 FIP Congress in Dublin (Ireland)
  • Type: Poster
  • By: KUMAMOOT, Takuya (Musashino University, Faculty of Pharmacy, Nishitokyo, Japan)
  • Co-author(s): Nakajima, M. (Musashino University, Nishitokyo, Japan)
    Katakawa, K. (Musashino University, Nishitokyo, Japan)
    Yoshizawa, Y. (Chiba University, Chiba, Japan)
    Saiki, R. (Chiba University, Chiba, Japan)
    Nishimura, K. (Chiba University, Chiba, Japan)
    Igarashi, K. (AminePharma, Chiba University, Chiba, Japan)
  • Abstract:

    1. Background

    N-Methyl-D-aspartate (NMDA) receptors have been implicated in learning and memory, and may also play a central role in various conditions leading to neuronal degradation. Overexcitation of NMDA receptors may result in neuronal cell injury or death. Therefore, NMDA receptor antagonists could be of therapeutic benefit to a number of..

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Last update 4 October 2019

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