The role of securin on the regulation of apoptosis induced by ACP-93 in human colorectal cancer cells

• In: Posters
• At: Dublin (Ireland) (2013)
• Type: Poster
• By: SHIH, Chen-Yi (Department of Pharmacy, Tainan Municipal Hospital, Taiwan, Tainan, China Taiwan)
• Co-author(s): Chao, J. (Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, China Taiwan)
  Chiu, T. (Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien, China Taiwan)
  Chen, C. (Department of Chemistry, National Dong Hua University, Hualien, China Taiwan)
  
• Abstract:

  
  Background:
  ACP-93 is a new synthetic compound that displays anticancer ability in the human colon cancer cells; however, the apoptotic mechanism by ACP-93 is poorly understood. Securin, also known as pituitary tumor transforming gene (PTTG), regulates proliferation and metastasis in cancer cells.
  
  Aims:
  To investigate the role of securin on the

  ..

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