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YC-1 enhances ox-LDL-mediated macrophage foam cell formation via a cGMP-related pathway

  • At: 2013 FIP Congress in Dublin (Ireland)
  • Type: Poster
  • By: TSUI, Leo (Graduate Institute of Medical Sciences, Taipei Medical University, College of Medicine, Taipei Medical University, Taipei city, China Taiwan)
  • Co-author(s): Fong, Tsorng-Harn (Department of Anatomy, School of Medicine, Taipei Medical University, Taipei city, China Taiwan)
  • Abstract:


    I. Background



    YC-1, the anti-cancer candidate, could directly activate soluble guanylyl cyclase (sGC) and increase cyclic guanosine monophosphate (cGMP) level. Our previous study found that YC-1 inhibited oleate-mediated lipid droplet formation and induced lipolysis in RAW 264.7 macrophages.


    II. Aim



    However, the effect of YC-1 on oxidized low

    ..

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Last update 4 October 2019

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