YC-1 enhances ox-LDL-mediated macrophage foam cell formation via a cGMP-related pathway
- At: 2013 FIP Congress in Dublin (Ireland)
- Type: Poster
- By: TSUI, Leo (Graduate Institute of Medical Sciences, Taipei Medical University, College of Medicine, Taipei Medical University, Taipei city, China Taiwan)
- Co-author(s): Fong, Tsorng-Harn (Department of Anatomy, School of Medicine, Taipei Medical University, Taipei city, China Taiwan)
YC-1, the anti-cancer candidate, could directly activate soluble guanylyl cyclase (sGC) and increase cyclic guanosine monophosphate (cGMP) level. Our previous study found that YC-1 inhibited oleate-mediated lipid droplet formation and induced lipolysis in RAW 264.7 macrophages.
However, the effect of YC-1 on oxidized low.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.