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Chitosan-FAP-B nanoparticles: Novel non viral vectors for gene delivery to the lung epithelial cells

  • At: 2012 FIP Congress in Amsterdam (the Netherlands)
  • Type: Poster
  • By: MOHAMMADI, Zohreh (Avicenna Research Institute, ACECR, Tehran, Iran, Nanobiotechnology Research Center, Tehran, Iran)
  • Co-author(s): Dorkoosh, F. (Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical S, Tehran, Iran)
    Abolhassani, M. (Nosco Pharmaceuticals, 105, rue de la convention, 75015 Paris, France;, Paris, France)
    Hosseinkhani, S. (Department of Biochemistry, Faculty of Science, Tarbiat Modares University, Tehr, Tehran, Iran)
    Gilani, K. (Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical S, Tehran, Iran)
    Amini, T. (Nobleceuticals Ltd, Birmingham, United Kingdom, Birmingham, United Kingdom)
    Rouholamini Najafabadi, A. (Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical S, Tehran, Iran)
    Rafiee Tehrani, M. (Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical S, Tehran, Iran)
  • Abstract:

    Background:
    Gene delivery using cationic polymers such as chitosan shows good biocompatibility, but reveals low transfection efficiency. Fibronectin Attachment Protein of Mycobacterium bovis (FAP-B) can be considered as a new targeting ligand and can improve transfection rates in epithelial cells.
    Aim:

    In this study, a non-viral gene vector with

    ..

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Last update 4 October 2019

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