Nitrofurantoin permeability through Caco-2 cells: a parameter to develop new oral 5-nitro-heterocyclic compounds with potential activity against Multirresistant Staphylococcus aureus
- At: 2012 FIP Congress in Amsterdam (the Netherlands)
- Type: Poster
- By: BALLERINI FERNANDES, Mariane (University of São Paulo, Pharmacy, São Paulo, Brazil)
- Co-author(s): Gonçalves, J.E. (University of São Paulo, São Paulo, Brazil)
Costa Tavares, L. (University of São Paulo, São Paulo, Brazil)
Storpirtis, S. (University of São Paulo, São Paulo, Brazil)
New 5-nitro-heterocyclic compounds have shown potential..
activity against multidrug-resistant
, being important and necessary the oral bioavailability evaluation as next stage in the development of a new drug. Nitrofurantoin, a 5-nitro-heterocyclic agent used in urinary infections, presents high oral bioavailability (?90%). This The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.