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Nitrofurantoin permeability through Caco-2 cells: a parameter to develop new oral 5-nitro-heterocyclic compounds with potential activity against Multirresistant Staphylococcus aureus

  • At: 2012 FIP Congress in Amsterdam (the Netherlands)
  • Type: Poster
  • By: BALLERINI FERNANDES, Mariane (University of São Paulo, Pharmacy, São Paulo, Brazil)
  • Co-author(s): Gonçalves, J.E. (University of São Paulo, São Paulo, Brazil)
    Costa Tavares, L. (University of São Paulo, São Paulo, Brazil)
    Storpirtis, S. (University of São Paulo, São Paulo, Brazil)
  • Abstract:

    New 5-nitro-heterocyclic compounds have shown potential
    in vitro

    activity against multidrug-resistant
    S. aureus

    , being important and necessary the oral bioavailability evaluation as next stage in the development of a new drug. Nitrofurantoin, a 5-nitro-heterocyclic agent used in urinary infections, presents high oral bioavailability (?90%). This

    ..

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Last update 4 October 2019

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