Determination of piperphentonamine and metabolites M1 and M6 in human plasma and urine by LC/MS/MS and its application in a pharmacokinetics study in Chinese healthy volunteers
- At: 2012 FIP Congress in Amsterdam (the Netherlands)
- Type: Poster
- By: SHI, Aixin (Beijing Hospital of Ministry of Health, Department of Pharmacy, Beijing, China)
- Co-author(s): Hu, H.X. (Beijing Hospital of Ministry of Health, Beijing, China)
Li, L.K.X. (Beijing Hospital of Ministry of Health, Beijing, China)
Wan, W.H.Y. (Huayin, Guangzhou, China)
Background: Piperphentonamine hydrochloride(PPTA) is a new calcium sensitizer...
Aims: A simple and sensitive liquid chromatography-tandem mass spectrometry(LC/MS/MS) method for determination of piperphentonamine and its metabolites M1 and M6 was developed for the first time and applied to a pharmacokinetics study.
Methods:Protein precipitation was The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.