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Effect of antioxidants on the stability of ONO-1301, a novel long-acting prostacyclin agonist, loaded in PLGA microspheres

  • At: 2012 FIP Congress in Amsterdam (the Netherlands)
  • Type: Poster
  • By: UCHIDA, Takahiro (Mukogawa Womens University, Faculty of Pharmaceutical Sciences, Nishinomiya city, Japan)
  • Co-author(s): Hazekawa, M. (Mukogawa Womens University, Nishinomiya city, Japan)
    Yoshida, M. (Mukogawa Womens University, Nishinomiya city, Japan)
  • Abstract:

    The purpose of this study was to evaluate the effect of antioxidant on the stability of poly(lactide-co-glycolide) microspheres (PLGA MS) containing ONO-1301, a novel long-acting prostacyclin agonist.Firstly, the structural formula of the degradation product of ONO-1301 was determined using liquid chromatography–nuclear magnetic resonance/mass

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Last update 4 October 2019

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