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Rabbits gastrointestinal fluids: a good model for drug solubility prediction in humans?

  • At: 2012 FIP Congress in Amsterdam (the Netherlands)
  • Type: Poster
  • By: DE MATOS AFONSO PEREIRA, Francisco (UCL School of Pharmacy, Pharmaceutics, London, United Kingdom)
  • Co-author(s): Basit, A.W. (UCL School of Pharmacy, London, United Kingdom)
  • Abstract:

    I. Background

    Several animal species are used as models for studying oral drug delivery for solid oral dosage forms, but are they suitable?
    II. Aims

    This study evaluates the degree of influence of pH, buffer capacity, surface tension and osmolality of rabbit GIT (gastrointestinal tract) fluids on the solubility of prednisolone and mesalamine (5-ASA),


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Last update 4 October 2019

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