Rabbits gastrointestinal fluids: a good model for drug solubility prediction in humans?
- At: 2012 FIP Congress in Amsterdam (the Netherlands)
- Type: Poster
- By: DE MATOS AFONSO PEREIRA, Francisco (UCL School of Pharmacy, Pharmaceutics, London, United Kingdom)
- Co-author(s): Basit, A.W. (UCL School of Pharmacy, London, United Kingdom)
Several animal species are used as models for studying oral drug delivery for solid oral dosage forms, but are they suitable?
This study evaluates the degree of influence of pH, buffer capacity, surface tension and osmolality of rabbit GIT (gastrointestinal tract) fluids on the solubility of prednisolone and mesalamine (5-ASA), The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.