Design, synthesis and pharmacological evaluation of celecoxib analogues

• In: Medicinal Chemistry Posters
• At: Hyderabad (India) (2011)
• Type: Poster
• Poster code: MC-P-11
• By: MUHAMMED, Shahin (Acharya & B.M Reddy College of Pharmacy, Bangalore, India)
• Co-author(s): Das, Amit Kumar (Acharya & B.M Reddy College of Pharmacy, Bangalore, India)
  
• Abstract:

  Celecoxib is a selective COX-2 inhibitor, which has got fewer side effects compared to COX-1 inhibitors. Aim of the present study was to design, synthesize and evaluate some celecoxib analogues for their anti-inflammatory, anti-convulsant and depressant activities. Chalcone was synthesized by Claisen Schmidt condensation reaction from acetophenone ..

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