Study of fast release cefpodoxime proxetil tablet using complexation and solid dispersion techniques

• In: Industrial Pharmacy Posters
• At: Hyderabad (India) (2011)
• Type: Poster
• Poster code: IPS-P-01
• By: BUDHATHOKI, Uttam (Department of Pharmacy, Kathmandu University, Dhulikhel, Nepal)
• Co-author(s): Aryal, Bishnu Prasad (Department of Pharmacy, Kathmandu University, Dhulikhel, Nepal)
  Thapa, Panna (Department of Pharmacy, Kathmandu University, Dhulikhel, Nepal)
  
• Abstract:

  Background information: Bioavailability of cefpodoxime proxetil (CP) is 50% due to solubility, gelation and luminal metabolism. Complexation in stoichiometric ratio of 1:1 for β-cyclodextrins (β-CD) and CP was more sensitive to microbes than uncomplexed one and solid dispersion in polyvinylpyrrolidone K-30 improved its bioavailability. In

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