Effect of cefepime on startle amplitude and prepulse inhibition of startle reflex in rats: manipulation of gaba-a receptor function with midazolam.
- At: 2005 FIP Congress in Cairo (Egypt)
- Type: Poster
- By: KHALIFA, AMANI (Faculty of Pharmacy Ain shams university, PHARMACOLOGY & TOXICOLOGY, Cairo, Egypt)
Disruption of prepulse inhibition (PPI) of startle response is manifested in schizophrenia and Huntington’s disease among other neuropsychiatric disorders characterized by sensorimotor gating deficit. Antagonism of GABA(A) receptor function was documented to enhance PPI response. Nevertheless, contradicting reports suggest that GABA(A).. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.