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Receptors and applications in biology and personalized medicine: CCR5/CXCR4receptors and fusion inhibitors in HIV-1 disease

  • At: Istanbul (Turkey) (2009)
  • Type: Presentation
  • By: GOFF, Stephen P. (Columbia University, Columbia, United States of America)
  • Abstract:

    The HIV-1 envelope protein mediates entry of the virus into the cell through a specific receptor (CD4) and various coreceptors on the cell surface. Virus isolates typically exhibit a selectivity for utilization of either CCR5 (R5 virus), CXCR4 (X4 virus), or both (dual tropic virus). While the initially transmitted isolates are almost always R5


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Last update 4 October 2019

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