Enhancement of dissolution rate of acyclovir by complexation with hydroxypropyl ?-cyclodextrin using different techniques
- At: 2005 FIP Congress in Cairo (Egypt)
- Type: Poster
- By: EL-GAZAYERLY (Faculty of Pharmacy, Pharmaceutics, Cairo, Egypt)
- Co-author(s): Mursi (Faculty of Pharmacy, CAIRO, Egypt)
El-Wafa (Faculty of Pharmacy, CAIRO, Egypt)
Aiming to increase the water solubility of the poorly soluble drug, acyclovir, complexes of the drug with hydroxypropyl ß-cyclodextrin (HPßCD) were prepared. Complexes between the drug and HPßCD were prepared as physical mixtures and lyophilized forms. Phase solubility study was performed in phosphate buffer saline at concentrations 5, 10, 15 .. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.